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aderfp633 · Inscrit le: 27 Sep 2011 Messages: 7915 Localisation: England

{Resistant cells to blame for multiple myeloma relapse}
Featured VideoClose More Video Phil James' music therapy brings back distant memories in seniors #file_links[D:\keywords12.txt,1,S] Athletes Influencing Kids to Eat 'Junk Food' “I told my mom that I wanted to be a girl” Milliken Park recreational pickleball league Toronto researchers have discovered why patients with multiple myeloma, an incurable cancer of the bone marrow, inevitably relapse even after their disease has been in remission for years.The mainstay drug treatment used for the disease — Velcade, a proteasome inhibitor — is effective at killing the plasma cells that make up most of the tumour. But immature progenitor cells, which are the root cause of the disease, are resistant to the drug.Unaffected by the drug, the progenitor cells proliferate and mature to reboot the disease process, even in patients who appear to be in complete remission, according to the study published online in Cancer Cell.“If you thi #file_links[D:\keywords14.txt,[url=http://www.moncler-sale.org]moncler on sale[/url],1,S] nk of multiple myeloma as a weed, then proteasome inhibitors such as Velcade are like a persnickety goat that eats the matur #file_links[D:\keywords11.txt,1,S] e foliage above ground producing remission, but doesn’t eat the roots, so that one day the weed returns,” said principal investigator Dr. Roger Tiedemann, a hematologist specializing in multiple myeloma and lymphoma at the Princess Margaret Cancer Centre and University of Toronto.“Our findings reveal a way forward toward a cure for multiple myeloma, which involves targeting both the progenitor cells and #file_links[D:\keywords13.txt,1,S] th #file_links[D:\keywords15.txt,1,S] e plasma cells at the same time,” he said.
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